Seminar 19th December 2012 2:30 p.m. 54/10031
Optimal design in nonlinear mixed effects models with application in pharmacokinetics
France Mentre
Inserm - University Paris Diderot
- Web page
- http://www.southampton.ac.uk/s3ri/events/seminars/statrsch/index.php
- Categories
- Agent-Based Negotiation, Bioinformatics, Biomathematics, Biomedical, Biometrics, Complex Systems, Data Acquisition, Data Management, Epidemiology, Monte Carlo, Scientific Computing
- Submitter
- Dave Woods
France Mentre is a Professor of Biostatistics and, since 2003, Director of the research unit UMR 738 of University Paris Diderot and INSERM called "Models and Methods for the therapeutic assessment of chronic diseases" and since 2009 head of the team “ Biostatistical Modelling and Pharmacometrics” created in January 2009. Her main methodological research areas include
Exact estimation methods in nonlinear mixed-effect models
Design optimisation in nonlinear mixed-effect models (wwww.pfim.biostat.fr)
Model evaluation in nonlinear mixed-effect models (www.npde.biostat.fr)
Model selection, covariate tests and pharmacogenetics
Modelling data from interaction or bioequivalence studies
Her main application areas include
Pharmacology and pharmacogenetics of antiretroviral drugs in HIV patients
Variability of the response to oral anticoagulant drugs
Pharmacokinetic/pharmacodynamic parameters, efficacy and antibiotic resistance
Chemosensitivity to antimalarial agents
Evolution of biomarkers of the Gaucher disease, with or without treatment
Infectious endocarditis
Bioequivalence of monoclonal antibodies