Computational Modelling Group

Dr Johanna Jefferies

Research Fellow
Medicine (FM)
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My research spans the interface between clinical microbiology and academic public health. My major area of research has been the molecular epidemiology of colonising and invasive strains of the opportunistic human pathogen Streptococcus pneumoniae. I am now focussing on polymicrobial infection and carriage, particularly peri-conjugate vaccine introduction.

I am working with Dr Stuart Clarke (Senior clinical lecturer and honorary consultant in Health Protection, School of Medicine) on projects to sequence multiple genomes of S.pneumoniae and other pathogens. I am also interested in utilising NextGen technology to perform microbial community profiling of human respiratory and other mucosa.

I am interested in bacterial communities growing in biofilms and how this mode of growth may facilliate persistence and lead to chronic infections. I am a co-applicant on a Gates Foundation study to identify novel pneumococcal vaccine targets and on a BBSRC/Pfizer CASE studentship with Dr Jeremy Webb (BBSRC David Phillips Senior Research Fellow and Lecturer in Microbiology, School ofBiological Sciences) and Dr Stuart Clarke to investigate multi-species biofilms.

Research Interests

Life sciences simulation: Bioinformatics, Epidemiology, NextGen Sequencing