Computational Modelling Group

Postdoctoral research fellow in Bioinformatics

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16th May 2011
Bioinformatics, Biomedical, Biomolecular Organisation, Complex Systems, Data Management, Database, Evolution, Iridis, Java, Linux, MySQL, Python, R, Structural biology, Systems biology
Richard Edwards

Many protein-protein interactions are mediated by Short Linear Motifs (SLiMs): short stretches of proteins (5-15 amino acids long), of which only a few positions are critical to function. These motifs are vital for biological processes of fundamental importance, such as signalling pathways and targeting proteins to the correct part of a cell. The primary objective of this project is to integrate a number of leading computational techniques to predict novel SLiMs and, in so doing, add crucial detail to protein-protein interaction networks. This will generate a valuable resource of potential SLiMs, including defined occurrences and interactions.

The project will use a number of computational and sequence analysis techniques. Basic programming skills are essential. Experience with database design, HPC and web programming are highly desirable. You will be required to develop a thorough knowledge of SLiM-mediated protein-protein interactions and should therefore be comfortable with biological literature, biochemistry, molecular evolution and structural biology. Please note that the project is 100% computational.

A background in either computer science or biology, with a PhD in a relevant subject area, is essential. Previous research experience (PhD or Postdoctoral) in computational biology is highly desirable. Candidates with a computer science background must demonstrate an interest and aptitude for molecular biology. Similarly, candidates with a biology background must demonstrate an interest and aptitude for computer programming. Project management skills and independent research experience are desirable. You should be an enthusiastic researcher, a good teamworker and an excellent communicator.

The position is full-time and available immediately for a period of three years. Start date is flexible but the successful candidate must be in post by September 2011. The application deadline is 16 May 2011.

Please see visit Dr Edwards' Homepage for more information. Informal enquiries are welcome.