Computational Modelling Group

Seminar  17th March 2016 1 p.m.  Building 7, room 3021

An overview of selected projects in computational biomechanics: fluid-structure interaction for haemodynamics, and adaptive bone remodelling in reverse total shoulder arthroplasty

Dr. Andrew McBride
University of Glasgow and University of Cape Town

Advanced Materials, Biomathematics, Biomechanics, Biomedical, C++, Complex fluids, Complex Systems, Computer Science, DEAL, Elasticity, Finite elements, Fluid Dynamics, fluid structure interaction, Healthcare modelling, Materials, Medical Imaging, Multi-physics, Multi-scale, Quantitative Biology, Scientific Computing, Structural biology, Structural dynamics, Surface imaging, Tribology, Visualisation, Voxel imaging
Georges Limbert

The aim of this presentation is to give an overview of two current computational biomedical engineering projects that I’m involved in.

The first project aims to improve the detailed understanding of haemodynamics and vascular mechanics in arteriovenous shunting. A combination of new magnetic resonance image (MRI) technology and computational modelling of in vivo blood flow characteristics aims to improve therapeutic strategies and subsequent monitoring of diseases requiring vascular interventions. This focus of our contribution to this collaborative project is the development of a robust and efficient computational model accounting for the fluid-structure interaction (FSI). The model allows for patient-specific geometries and boundary conditions obtained from the MRI data. The MRI data also serves to validate the model.

The second project concerns reverse total shoulder arthroplasty: a procedure for the treatment of gleno- humeral joint disease among patients with severe rotator cuff deficiency. In this procedure, the medial head of the humerus is removed and a replaced by a cup-shaped implant. A hemispherical implant (the glenosphere) is then attached to the glenoid. The procedure is widely used but several complications can occur. These include scapula notching, and instability of the glenosphere due to loosening of the fixating screws. The hypothesised cause of the instability is bone remodelling due to the significant changes in the loading on the scapula. Remodelling is the process whereby bone undergoes changes in geometry, density and constitutive response in order to optimise its structure to the loading environment. The objective of this collaborative project is to better understand the post-operative loading environment and the subsequent remodelling process using computational modelling.

Biography Andrew graduated with a MSc (Civil Engineering) from the University of Cape Town (UCT) in 2000. He spent a brief time working as a Civil Engineer, before embarking on a research career in the Centre for Minerals Research at UCT. The focus of his work was on the simulation of granular systems with application to the minerals processing industry. During this period, he embarked on a PhD with Prof. Daya Reddy on various aspects of the theory and computation of non-classical plasticity. After graduating in 2008, he spent two years as a research officer in the Centre for Research in Computational and Applied Mechanics (CERECAM, UCT) working on problems in plasticity, biomechanics, granular flow and homogenization. In 2010, he moved to the Chair of Applied Mechanics at the University of Erlangen– Nuremberg to pursue his postdoctoral studies with Prof. Paul Steinmann. The focus of the research was on non-classical models of diffusion, surface elasticity theory and computational homogenization. In mid 2012 he returned to CERECAM as a Senior Researcher. Throughout his career he has been interested in the use of quality, open-source tools for scientific computation. Since the beginning of 2016, Andrew has been a Senior Lecturer at the University of Glasgow in the Division of Infrastructure and Environment.