Computational Modelling Group

Modelling neuronal activity at the knee joint

1st October 2010
30th September 2013
Research Team
Gwen Palmer
Mark Taylor, Tiina Roose

Neural response from posterior articular nerve (PAN) during flexion and extension.

The function of the knee joint is reliant on proprioception, which involves the response of nerve endings in the tissues at the joint. There are four types of nerve endings that are known to be present at the knee joint,all of which will need to be modelled; Ruffini, Paciniform, Golgi and Nociceptor.

For the first stage of this project, it was necessary to develop a model that represents each of the nerve endings. The Hodgkin-Huxley model has been adapted to represent the behaviour of these four types of nerve endings. A finite element model of a feline knee joint was then developed, as most of the available data is related to the feline knee. Strains at the soft tissues of the knee joint were input to the relevant nerve model, and the individual neural response summed. This is done for a range of knee positions, so it is possible to see how the global neural response changes as the joint moves.

It is also possible to observe how the neural response changes when the knee joint is damaged. For example, on resection of the anterior cruciate ligament (ACL), the posterior articular nerve displays a significant increase in the neural response during flexion and extension. This is supported by data published by Gomez-Barrena et al (1997).


Life sciences simulation: Biomedical, Neuroscience

Physical Systems and Engineering simulation: Biomechanics

Algorithms and computational methods: Multi-physics, Multi-scale

Simulation software: Abaqus

Visualisation and data handling software: Avizo

Programming languages and libraries: Matlab

Transdisciplinary tags: Complex Systems