Multiscale Modelling of Cellular Calcium Signalling

Homepage: http://eprints.soton.ac.uk/id/eprint/350651
Started: 1st October 2008
Ended: 1st October 2012
Research Team: Dan Mason
Investigators: Hans Fangohr, Jonathan Essex

Multiscale modelling up to the cellular level: an overview of relevant simulation methods.

The ability to design effective medicines that treat disease requires a detailed knowledge of the associated natural processes. These natural processes operate on a range of complex spatio-temporal scales.

Computational modelling allows us to investigate such processes, however these often provide detail only at a single spatiotemporal scale. Multiscale modelling aims to combine or link these scales represented by computational models, such that information is passed between different types of simulation.

This project developed a multiscale model of cellular calcium signalling through extension of existing models. The pancreatic acinar cell was chosen for this treatment, owing to the polarised structure, range of signalling events, and disease states that are characteristic of this cell type.

Computational Modelling Group

Multiscale Modelling of Cellular Calcium Signalling

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