Transgenerational inheritance of allergy in a multi generational cohort
- Started
- 10th January 2011
- Ended
- 30th December 2016
- Investigators
- John Holloway
DNA methylation profiles from cord blood derived DNA
The aim of this project is to determine the vertical transmission of DNA methylation by identification of CpG sites by microarray analysis of 450,000 CpG sites in 252 women of the IoW cohort that are associated with allergic sensitization and testing whether the identified methylation patterns are vertically transmitted to their offspring and whether modifiable environmental conditions during gestation affect DNA methylation.
Categories
Life sciences simulation: Bioinformatics, Biomedical, Epigenetics