Computational Modelling Group

Transgenerational inheritance of allergy in a multi generational cohort

10th January 2011
30th December 2016
John Holloway

DNA methylation profiles from cord blood derived DNA

The aim of this project is to determine the vertical transmission of DNA methylation by identification of CpG sites by microarray analysis of 450,000 CpG sites in 252 women of the IoW cohort that are associated with allergic sensitization and testing whether the identified methylation patterns are vertically transmitted to their offspring and whether modifiable environmental conditions during gestation affect DNA methylation.


Life sciences simulation: Bioinformatics, Biomedical, Epigenetics