Integrated in silico prediction of protein-protein interaction motifs

Started: 29th June 2011
Ended: 28th June 2014
Research Team: Nicolas Palopoli, Kieren Lythgow
Investigators: Richard Edwards

The aim of my research is to identify sites on proteins that are critical for their interactions with other proteins. Many protein-protein interactions are mediated by Short Linear Motifs (SLiMs) which are short proteins typically 5-15 amino acids long containing only a few positions crucial to function. These motifs play an essential role in many biological processes including signalling pathways and subcellular localisation. I aim to integrate a number of leading computational techniques to predict novel SLiMs and add crucial detail to protein-protein interaction networks. Current software available for SLiM discovery and analysis including SLiMFinder, SLiMSearch and CompariMotif can be found here.

This project is funded by a BBSRC New Investigator Award to Dr Richard Edwards (BB/I006230/1).

Computational Modelling Group

Integrated in silico prediction of protein-protein interaction motifs

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