Computational Modelling Group

Integrated in silico prediction of protein-protein interaction motifs

29th June 2011
28th June 2014
Research Team
Nicolas Palopoli, Kieren Lythgow
Richard Edwards

The aim of my research is to identify sites on proteins that are critical for their interactions with other proteins. Many protein-protein interactions are mediated by Short Linear Motifs (SLiMs) which are short proteins typically 5-15 amino acids long containing only a few positions crucial to function. These motifs play an essential role in many biological processes including signalling pathways and subcellular localisation. I aim to integrate a number of leading computational techniques to predict novel SLiMs and add crucial detail to protein-protein interaction networks. Current software available for SLiM discovery and analysis including SLiMFinder, SLiMSearch and CompariMotif can be found here.

This project is funded by a BBSRC New Investigator Award to Dr Richard Edwards (BB/I006230/1).


Life sciences simulation: Bioinformatics, Biomedical, Biomolecular Organisation, Evolution, Structural biology, Systems biology

Programming languages and libraries: Java, Python, R

Computational platforms: Iridis, Linux, Windows

Transdisciplinary tags: Complex Systems, HPC